Do not stop taking it without consulting your doctor. What happens if I stop taking isosorbide mononitrate (Monoket)? you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. The extended-release tablet usually is taken once daily in the morning. Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. Medicines containing Isosorbide Mononitrate. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen. Do not double the dose to catch up. Headaches can be a sign that the medicine is working, and they might lessen with continued use of the medication. Isosorbide mononitrate (Monoket) is available as a generic medication and may be significantly cheaper compared to the brand version. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. Zhonghua Yi Xue Za Zhi (Taipei). information highlighted below and resubmit the form. The site is secure. This medication belongs to a class of drugs known as nitrates. What side effects can this medication cause? Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. What should I know about storage and disposal of this medication? Melanoma is one of the most dangerous forms of skin cancer which develops in the skin cells that produce melanin ( the pigment that gives your skin its color). Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. coma (loss of consciousness for a period of time). Do not change the dosing times unless directed by your doctor. If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. Does Alcohol Raise Your Blood Pressure? Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.AvanafilRiociguatSildenafilTadalafilVardenafil. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. 7.6 out of 10 from a total of Accessed Sept. 7, 2022. Careers. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. 41% of reviewers reported a positive effect, while 50% reported a negative effect. Before Would you like email updates of new search results? If this worries you, talk to your doctor or pharmacist about other options. This content does not have an English version. A randomized, double-blind, cross-over study. You may report side effects to the FDA at 1-800-FDA-1088. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. isosorbide mononitrate (Rx) Brand and Other Names: Imdur, Monoket, more. Many common herbal supplements interact with common heart medicines. 2017; doi:10.1016/j.jacc.2016.11.078. Which drugs or supplements interact with isosorbide mononitrate? Herbal supplements are natural, so they must be safe, right? https://naturalmedicines.therapeuticresearch.com. https://naturalmedicines.therapeuticresearch.com. Making any changes without doctor's advice can be dangerous. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. You may report side effects to the FDA at 1-800-FDA-1088. PMC If you have ever had an allergic reaction to a medicine. For haemoglobin formation vit. Therefore, oral nitrates should not be used by patients who are sensitive to the effects of hypotension, such as those with pre-existing hypotension, shock, vascular collapse or significant cerebrovascular disease, significant anaemia or hypothyroidism. I would rather take the chance of a heart attack than have no quality of life. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. Nitrates (eg, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin). Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. It's usually not a problem for most people unless you drink alcohol or take other medications that can also lower your blood pressure. All rights reserved. Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Please enable it to take advantage of the complete set of features! Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Watch for any symptoms that you may be having a drug interaction, such as: Mayo Clinic does not endorse companies or products. The tablet usually is taken two or three times daily. It might help to take isosorbide mononitrate and dinitrate after meals. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: It's not suggested to take St. John's wort if you take blood thinners. Let your provider know if they are excessive. This does not necessarily mean no interactions exist. Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. Herbal medications in cardiovascular medicine. Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Be sure to follow your provider's instructions about when to take isosorbide mononitrate (Monoket). To help you remember, take it at the same times each day. 8600 Rockville Pike Cleophas TJ, Niemeyer MG, van Der Wall EE. Store at room temperature away from light and moisture. This should pass after a few days. Elsevier; 2021. https://www.clinicalkey.com. Is not subject to the Controlled Substances Act. Take the container with you, even if it is empty. Consult your doctor for more details. Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. This makes it easier for your heart to pump, relieving heart-related chest pain. Copyright 2023 IBM Watson Health. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Aspirin has an average rating of Keep this medication in the container it came in, tightly closed, and out of reach of children. These side effects may go away during treatment as your body adjusts to the medicine. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction. FOIA Some brands of isosorbide mononitrate tablets should be taken two or three times a day. Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. Glyceryl trinitrate (GTN) is commonly prescribed for this. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomachanxietyback painbelchingblemishes on the skinbloatedbreast painburning feeling in the chest or stomachburning, dry, or itching eyeschange in color visionchanges in visioncold sweatscongestionconstipationcontinuing ringing or buzzing or other unexplained noise in the earscough producing mucusdecreased interest in sexual intercoursedifficulty seeing at nightdifficulty with movingdischarge, excessive tearingdouble visiondrooping upper eyelidsdull ache or feeling of pressure or heaviness in the legsearacheexcess air or gas in the stomach or intestinesfeeling of constant movement of self or surroundingsfeeling of warmthfeeling unusually coldfrequent urge to defecatefrozen shoulderfull feelinghearing lossheartburnhyperventilationinability to have or keep an erectionincreased appetiteincreased sensitivity of the eyes to sunlightincreased sputumindigestionirritabilityitching skin near damaged veinslack or loss of strengthloss in sexual ability, desire, drive, or performancemuscle or bone painmuscle stiffness or weaknessnightmaresnoisy breathingpain or tenderness around the eyes and cheekbonespassing gaspimplespoor concentrationrashredness of the face, neck, arms, and occasionally, upper chestredness, pain, swelling of the eye, eyelid, or inner lining of the eyelidredness, swelling, or soreness of the tonguerestlessnessseeing doublesensation of spinningsleepiness or unusual drowsinesssmall clicking, bubbling, or rattling sounds in the lung when listening with a stethoscopesmall lumps under the skinsore mouth or tonguestiff neckstomach bloating, burning, cramping, or painstomach discomfort or upsetstraining while passing stoolstuffy nosesudden sweatingswollen feet and anklestender, swollen glands in the necktenderness in the stomach areaterrifying dreams causing sleep disturbancestooth disordertrouble swallowinguncontrolled twisting movements of the neckvoice changesweight losswhite patches in the mouth, tongue, or throatOther side effects not listed may also occur in some patients. Selected from data included with permission and copyrighted by First Databank, Inc. Below is the list of medicines, which contains Isosorbide Mononitrate as ingredient. Let your provider know if you are using any medications for erectile dysfunction before you start taking isosorbide mononitrate (Monoket). We comply with the HONcode standard for trustworthy health information. Seek alternatives to the CYP3A4 substrate when possible. Prescription and OTC If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. The authors assessed the occurrence of angina pectoris and headache by diary cards while taking into account the number of isosorbide dinitrate sublingual puffs and paracetamole tablets required. This activity describes the indications, action, and contraindications for isosorbide as a valuable agent in treating angina pectoris due to coronary artery disease, heart failure with reduced . Bethesda, MD 20894, Web Policies If your chest pain attacks happen more often, last longer, or become more severe at any time during your treatment, call your doctor. Daily headaches are a common side effect. Things to remember when you fill your prescription. Bauer B (expert opinion). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Advertising revenue supports our not-for-profit mission. 19 are major, 174 are moderate, and 2 are minor. [2] Consult your doctor for more details. Mayo Clinic. This is called tolerance, and it cannot be fixed by raising the dose of the medication. Accessed Sept. 7, 2022. Does Isosorbide Mononitrate interact with other medications? Some side effects may occur that usually do not need medical attention. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Generic alternatives may be available. This site complies with the HONcode standard for trustworthy health information: verify here. amlodipine, lisinopril, aspirin, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem. If you forget to take a dose, take it as soon as you remember. What special precautions should I follow? Isosorbide tablets are also used with other medications to treat heart failure. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Some of these interactions can be life-threatening. Contact your doctor immediately if you experience any of the following: The following side effects may get better over time as your body gets used to the medication. Isosorbide may not work as well after you have taken it for some time or if you have taken many doses. Call your doctor if you have any unusual problems while you are taking this medication. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Avoid combinations; the risk of the interaction outweighs the benefit. The herb licorice may lower warfarin levels and can add to digoxin's effects. Isosorbide mononitrate helps to prevent angina chest pain from developing. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. This medicine is for you. Get emergency help immediately if any of the following symptoms of overdose occur: bulging soft spot on the head of an infant, change in the ability to see colors, especially blue or yellow, feeling of constant movement of self or surroundings. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. It works and leaves the body quickly, so it needs to be taken twice a day. As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, excess air or gas in the stomach or intestines, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, stomach bloating, burning, cramping, or pain, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat. View more. This medicine is available only with your doctor's prescription. Liperoti R, et al. It is used to treat and prevent a wide range of different conditions. For details see our conditions. The short-acting tablet is usually taken as 10 mg to 40 mg by mouth 2 or 3 times daily with at least a 14 hour period of time per day where you don't take any doses. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Then, there was a two-week placebo washout, after which the alternative treatment was given. Natural Medicines. HHS Vulnerability Disclosure, Help Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. You need to take it every day in order for it to work. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Take extra precautions to avoid falling during your treatment with isosorbide. Try our Symptom Checker Got any other symptoms? government site. Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. All rights reserved. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Many herbal supplements can interact with prescription drugs. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. The longer you take isosorbide mononitrate, the more your body can become used to it (called tolerance), and then it can have less of an effect. If you have any problems with the way your liver works, or any problems with the way your kidneys work. Normal ecg doesn't rule out heart disease. It might help to keep the room cool and use a fan. Review/update the Isosorbide mononitrate vs. Amlodipine besylate, Isosorbide mononitrate vs. Bisoprolol fumarate, Isosorbide mononitrate vs. Diltiazem hydrochloride, Isosorbide mononitrate vs. Isosorbide dinitrate, Isosorbide mononitrate vs. Metoprolol succinate, Isosorbide mononitrate vs. Metoprolol tartrate, Isosorbide mononitrate vs. Nitrolingual pumpspray, Isosorbide mononitrate and Aspirin (7,880 reports), Isosorbide mononitrate and Furosemide (6,020 reports), Isosorbide mononitrate and Amlodipine (3,554 reports), Isosorbide mononitrate and Simvastatin (3,508 reports), Isosorbide mononitrate and Omeprazole (3,422 reports), Isosorbide mononitrate and Lisinopril (3,099 reports), Isosorbide mononitrate and Metformin (2,822 reports), Isosorbide mononitrate and Carvedilol (2,589 reports), Isosorbide mononitrate and Clopidogrel (2,524 reports), Isosorbide mononitrate and Acetylsalicylic acid (2,355 reports). If you buy any medicines, please check with a pharmacist that they are suitable for you to take with isosorbide mononitrate. 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (in Cafergot, in Migergot), methylergonovine (Methergine), methysergide (Sansert; no longer available in the U.S.), and pergolide (Permax; no longer available in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat.