The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Chemical Formula: (C6H10O5)n 1.4. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. CAS 9004-34-6. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. EINECS #: 232-674-9 1.7. 6 0 obj Well-recognized product that can do it all. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Are you looking for information about products and services by region? Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Fiber supplements can lessen the absorption of some . Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. 2021 Annual Report. However, consumption of large quantities of the material may have a laxative effect. It is, however, a good source of fibre. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Remove CAS #: 9004-34-6 1.6. Microcrystalline Cellulose / Avicel PH-102. Looking for FMC'searnings news? P}MFbN#[>r(y Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. B;vLZpHU%ChUyD+[ Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. cas:9032-51-3 msds CELLULOSE PAB. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Trademarks: Avicel PH-102. It is . Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. [FMC Study Number I92-1464]. << : 1. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. 0.25 - 0.37. q9;v80q>jZ Powder becomes slippery when wet. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . %PDF-1.3 Product and Company Identification . The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. q86@on$^X_HuH;3` Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Avicel PC 611 (FMC Biopolymer) Supplied by. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Medium size standard MCC grade, suited for the majority of directly compressible actives. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Safety Data Sheet for Cellulose microcrystalline 102331. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Cellulose microcrystalline for column chromatography. Revision No. Microcrystalline Cellulose E460 MSDS 1. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Some substance identifiers may have been claimed confidential, or may . Synergies to simplify formulation challenges and reduce operational costs. A family of polysaccharide products that allow distinctive drug delivery solutions. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. MATERIAL SAFETY DATA SHEET. : 5. : 160182 Date Approved: 05/25/2010 Revision No. We respect your privacy FMC Privacy Policy. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Chemical Formula: (C6H10O5)n 1.4. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. G2W4de=u183KGH{ vQ#4:1\wc Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Safety Data Sheet (SDS) Viewer. The figure below illustrates the structural organisation of cellulose within plants. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Hi, let us know if you have any questions as you visit our website. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Validity Area. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. All rights reserved. Page 1 of 8. These, in turn, are assembled into fibrils in the cell wall. Microcrystalline cellulose is a commonly used excipient in the . 1.3. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. We can send by Fedex, by ship or by plane according to international rules. Product Name: Microcrystalline Cellulose E460 1.2. 4 0 obj ( >> PharmaCentral 2021 . bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. . Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. endobj %PDF-1.5 ( stream Browse Avicel PH-101 and related products at MilliporeSigma. 6 Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! If you are already a ChemPoint customer then sign up for access to our online ordering website. 1 0 obj ). Avicel PC 611 Microcrystalline Cellulose. Magazine: Material safety data sheet - FMC Corporation. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. 9,LL!z In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. All Rights Reserved. Avicel PC 611 (FMC Biopolymer) . By producing Avicel . . The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Find answers in our support articles. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Have an order or account question? 130. 102331. ( 2 0 obj stream EMCOCEL XLM 90. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. >> Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Product Name Cellulose microcrystalline. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. The cellulose molecule is formed through repeated condensation of cellobiose units. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. l~5C MCC helps in the formation of spheres because of its . If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Molecular Weight null. <> This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. Thus, Avicel contributes no or very few calories to the food system. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Avicel Microcrystalline Cellulose Physical Properties. 8 0 obj Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. 1.3. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Your file is uploaded and ready to be published. Learn about FMC's differentiated biologically-based crop solutions. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. X\o^ At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Revision No. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Gloves, eye protection and a dust mask should be used. Doses up to 30 g per day appear to be . The table below shows the most common physicochemical parameters of this raw material. Protect them from sunshine or rain. Heavy metals, % NMT 0.001 In extrusion-spheronisation, it is the excipient of choice. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Have an order or account question, find answers in our Online Support articles. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. PDF (28.38 mb) 2022 Corporate Fact Sheet. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. MATERIAL SAFETY DATA SHEET. endstream The most. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM CAS #: 9004-34-6 . undefined. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. 4 0 obj Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. SCMm_>x^O9l (n. Biologicals by FMC. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. It works as a moisture sponge and permits the controlled growth of spheroids. Instead, they obtained a stable colloidal suspension. 3 0 obj II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Avicel Microcrystalline Cellulose: Chemical Identifiers. Earth Supplied Products LLC. High performance lubricant that brings more to the tablet. All Rights Reserved. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. It is hygroscopic and insoluble in water. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. It is a white, free-flowing powder. (&E. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. It . "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL PDF (4.11 mb) Footer menu 1. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. 4 0 obj Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Test Data Available. Document(s): certificate data msds. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! We are artists at heart and creators by nature. MSDS Ref. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Manufacturer: FMC BioPolymer. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. endobj 1 0 obj /Parent 3 0 R Production of Pharmaceutical Grade Microcrystalline Cellulose. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. } !1AQa"q2#BR$3br 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). ( w !1AQaq"2B #3Rbr : 160182. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) CoA. % The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Meet our leadership team. Wu, K. Zuurman, H.W. However, if handling bulk powders, observance of appropriate safeguards is recommended. Molecular weight: Not Applicable 1.5. Terms and Conditions Compliance Solutions Industries About 3E News & Events . No. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> <> ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" xv}O2' H~KEe9>G/,:9\i >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Manufactured by: China . << endobj ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? . In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Synonyms: Cellulose, Cellulose powder, Cotton linters. endobj LOT #: Available upon request. /MediaBox [0 0 612 792] Microcrystalline Cellulose (MCC) Manufacturing Industry. gac74 [#B6`Wnw7 Delivering efficient and robust formulations. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe << Explore how you can develop your career and bring your creative ideas to life at IFF. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge